Ren G#, Jin W#, Cui K#, Rodrigez J, Hu G, Zhang Z, Larson D, Zhao K. 2017 CTCF-mediated enhancer-promoter interaction is a critical regulator of cell-to-cell variation of gene expression. Mol Cell. 67:1049–1058
This study provides many new insights on the the function of CTCF:

Highlights

•3e Hi-C is a robust technique to measure genome-wide chromatin interactions
•CTCF binding correlates with enhancer activity and enhancer-promoter interaction
•CTCF stabilizes enhancer-promoter interaction and maintains robust gene expression
•Deletion of CTCF binding sites increases cell-to-cell variation of gene expression
Please see the the detail:
WordPress Themes